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Diapharma/Multiplate® TI – Thrombin Inhibitor Blood Collection Tube/MP0631/Bag/10x1.25ml
Description:
DISCONTINUED–REPLACEMENT:MP0600
Multiplate®TI–ThrombinInhibitorBloodCollectionTube isbloodcollectionsystem(microtubewithscrewcap) foruseinplatelet aggregationstudieswiththeMultiplate®plateletfunction analyzertoevaluatequalitativeplateletdisordersat physiologicalcalciumconditions. Hirudin,athrombininhibitorallowsanticoagulationof bloodwithoutinterferencewithphysiologicalcalcium levels.
DuringtheearlyphaseofMultiplate®development,citratedblood(either3.2%or3.8%)was usedforthesamplecollection. Itwasobservedthatsubjectsdidnotaggregateproperly,particularlywithADPasagoNIST.Citratecomplexescalciumandtherebypreventsclottingofthesample.However,calciumisalsoanimportantsecondmessengerforplateletaggregation.Forafullshapechangeandfullexposureofreceptorsontheplateletsurface,thereleaseofcalciumfromtheintracellularstoresisnecessary.Thebestsolutionforthisproblemistouseananticoagulantwhichdoesnotaffectthefreecalciumconcentrationinthesample, ideallyhirudin(adirectthrombininhibitor).Heparinhassomeactivatingpropertiesonplatelets;therefore,theuseofhirudinbloodispreferred.Toreducetheinfluenceofcalciumdepletionbycitrate,apartialrecalcificationusingtheNaCl/CaCl2diluentsolution isused.ThepartialrecalcificationcanleadtoadisaggregationphenomenonintheASPItestandRISTOtest.Forthesetests,0.9% salineisusedwhentesting citratedblood.
Composition:
Reagents,StorageandStABIlity
- MP0600: Multiplate®HirudinBloodTube(Double-Wall),50x3.0mltubes,anticoagulant:recombinanthirudin
- MP0601: Multiplate®HirudinBloodTube(Double-Wall),10x3.0mltubes,anticoagulant:recombinanthirudin
- MP0631: Multiplate®TI–ThrombinInhibitorBloodCollectionTube, 10x1.25mlmicrotubeswithscrewcap,anticoagulant:recombinanthirudin
Thespecifiedconcentrationofhirudinintheblood collectiontubesis>15µg/ml.Storetubesat4-25°C.Avoidexposuretodirectsunlight.
MeasurementPrinciple:
Refertopackageinsert.
