Description:
DISCONTINUED–REPLACEMENT:MP0280
Multiplate®GpIIbIIIaAntagoNISTisareagentkit foruseasquality controlinplateletaggregationstudiesontheMultiplate®Analyzer. TheGPIIb/IIIaAntagonistblockstheGPIIb/IIIareceptorandleadstoabolishedaggregationinallMultiplate®tests.
GpIIb/IIIaantagonistinhibitsthefibrinogen receptorsoftheplateletsthuspreventingtheiradhesion ontothesensorwiresoftheMultiplate® testcell.The reagentisemployedincombinationwiththeMultiplate activatingreagentsTRAPtest,ASPItest,COLtestand ADPtest.AdditionofGpIIb/IIIaantagonisttotheblood sampleleadstostronglyreducedaggregationin TRAPtest,ADPtest,ASPItestandCOLtest.
KitComposition:
Reagents, StorageandStABIlity
- MP0520:Multiplate®GpIIb/IIIaantagonist,synthetic GpIIb/IIIaantagonist(molecularweight495g/molina concentrationof50µg/ml),1x0.5ml,liquid,readyfor use.
- MP0280:Multiplate®GpIIb/IIIaantagonist,synthetic GpIIb/IIIaantagonist(molecularweight495g/molina concentrationof50µg/ml),3x0.5ml,liquid,readyfor use.
MeasurementPrinciple:
GpIIb/IIIaantagonistcontainsasyntheticinhibitoroftheplateletGpIIb/IIIareceptorwithamolecularweightof 495g/molataconcentrationof50µg/ml. BlockingtheGpIIb/IIIareceptorleadstoabolished aggregationintheMultiplate tests.Thisallowsthe assessmentofapositivecontrol(stronglyinhibited aggregation)inalltests. FurThermoreunspecificeffectsofchemicalspresentin thesampleontotheMultiplate® sensorscanbe elucidated(e.g.additionofoxidativesubstancesintothe blood).