Description:
Technoview®UFHControlHigh isaplasmacontrolwithahigh concentration(~0.5IU/ml)ofunfractionatedheparin(UFH) foruseasaqualitycontrolsampleinresearchmeasurementsofheparin.Itisoptimizedforusewithanti-Xachromogenicassaysand isfrequentlyusedinconjunctionwiththe Technoview®UFHlow controlandtheTechnoview®UFH calibratorsetinthe Technochrom®anti-Xachromogenicassay.
Advantages:
- 5vialsperkit-providescontrolsetwithalongshelflife
- Allowsforthevalidationofcalibrationcurvesforthemeasurementofunfractionatedheparin(UFH)inplasma
- Optimizedforusewithanti-Xa(withoutexogeneousantithrombin) research assays
ControlSetComposition:
- 5x1mlvials
Controlmaterialislyophilizedandpreparedfrompooledhumancitratedplasmasupplementedwithahigh concentrationofunfractionatedheparin.TheplasmacontainsstABIlizersbutnobactericideadditives.Itiscalibratedagainstthe5thInternationalStandardpreparationforUFH97/578.
Background:
HeparinisawidelyusedantithromboticagentthatcanbeadmiNISTeredviaanintravenousorsubcutaneousroute.Itisnaturallyoccurringandtypicallyderived from bovineorporcinetissue. Theanticoagulanteffect ofthissulfatedglycosaminoglycanresultsfromitsbindingtoantithrombin(AT),themajorinhibitorofthecoagulationcascade.Bindinginducesaconformationalchange intheAT molecule,whichgreatlyacceleratestheAT inhibitionofseveralcoagulation proteases.TheacceleratedinhibitionofthrombinandFactorXabyheparinistheprimarybasisforitsanticoagulationproperties.
Twoformsofheparinareusedtherapeutically:unfractionatedheparin(UFH),withanaveragemolecularweight(MW)of15,000andlowmolecularweightheparin(LMWH),withaMWbetween4,000and6,500.ThelowerMWresultsinLMWHactingprimarilyonFactorXa,whereasUFHefficientlyinhibitsboththrombinandFactorXa. Bothheparinformsshouldbemonitored.UFHcanbemeasured withanaPTTorananti-XachromogenicassaywhileLMWHshouldbemeasuredusingandanti-Xachromogenicassay.NotethatthiscontrolisforresearchuseonlyintheUSandCanada.
