Description:
Technoview®LMWControlHigh isaplasmacontrolwithahighconcentration(~1.1IU/ml)oflowmolecularweight(LMW) heparinforuseasaqualitycontrolsampleinresearchmeasurementsoflowmolecularweightheparin.Itisoptimizedforusewithanti-Xachromogenicassaysand isfrequentlyusedinconjunctionwiththe Technoview®LMWheparinlow andmedium controlsandtheTechnoview®LMWheparin calibratorsetinthe Technochrom®anti-Xachromogenicassay.
Advantages:
- 5vialsperkit-providescontrolsetwithalongshelflife
- Allowsforthevalidationofcalibrationcurvesforthemeasurementoflowmolecularweight(LMW) heparininplasma
- Optimizedforusewithanti-Xa(withoutexogeneousantithrombin) research assays
ControlSetComposition:
- 5x1mlvials
Controlmaterialislyophilizedandpreparedfrompooledhumancitratedplasmasupplementedwithahigh concentrationofLMW heparin.TheplasmacontainsstABIlizersbutnobactericideadditives.ItiscalibratedagainsttheInternationalStandardpreparationforLMWH,01/608.
Background:
HeparinisawidelyusedantithromboticagentthatcanbeadmiNISTeredviaanintravenousorsubcutaneousroute.Itisnaturallyoccurringandtypicallyderived from bovineorporcinetissue. Theanticoagulanteffect ofthissulfatedglycosaminoglycanresultsfromitsbindingtoantithrombin(AT),themajorinhibitorofthecoagulationcascade.Bindinginducesaconformationalchange intheAT molecule,whichgreatlyacceleratestheAT inhibitionofseveralcoagulation proteases.TheacceleratedinhibitionofthrombinandFactorXabyheparinistheprimarybasisforitsanticoagulationproperties.
Twoformsofheparinareusedtherapeutically:unfractionatedheparin(UFH),withanaveragemolecularweight(MW)of15,000andlowmolecularweightheparin(LMWH),withaMWbetween4,000and6,500.ThelowerMWresultsinLMWHactingprimarilyonFactorXa,whereasUFHefficientlyinhibitsboththrombinandFactorXa. Bothheparinformsshouldbemonitored.UFHcanbemeasured withanaPTTorananti-XachromogenicassaywhileLMWHshouldbemeasuredusingandanti-Xachromogenicassay.NotethatthiscontrolisforresearchuseonlyintheUSandCanada.
