Description:
“CountonDiapharma”AnticoagulationMeasurementFlyerTechnoview®apixabancontrolhigh isaplasmacontrolwithahighconcentrationofapixaban*(~300ng/ml)foruseasaqualitycontrolsample inresearchmeasurementsofapixiban.Itisoptimizedforusewithanti-Xachromogenicassaysand isfrequentlyusedinconjunctionwiththe Technoview®apixabanlowcontrolandtheTechnoview®apixabancalibratorsetinthe Technochrom®anti-Xachromogenicassay.
*ApixabanistheactivesubstanceinEliquis®.
Advantages:
- 5vialsperkit-providescontrolsetwithalongshelflife
- Allowsforthevalidationofcalibrationcurvesforthemeasurementofapixabaninplasma
- Optimizedforusewithanti-Xa(withoutexogeneousantithrombin) research assaysbut canbevalidated foruseinprothrombintime(PT)researchassays
ControlSetComposition:
- 5x1mlvials
Controlmaterialislyophilizedandpreparedfrompooledhumancitratedplasmasupplementedwithahighconcentrationofapixaban.TheplasmacontainsstABIlizersbutnobactericideadditives.Itiscalibrated,usingananti-Xaassay,inng/mlagainstaninternalreferencestandardandinIU/mlagainsttheinternationalstandardforlowmolecularweightheparin(LMWH)inplasma.
Background:
Apixaban(Eliquis®)isanoraldirectfactorXainhibitordrug.Itisprescribedbyahealthcareproviderandcan:
- reducetheriskofbloodclotsandstrokeinindividuals whohavenonvalvularatrialfibrillation;
- treatdeepveinthrombosis(DVT)andpulmonaryembolism(PE);and
- reducetheriskofDVTandPEinindividuals afterhiporkneereplacementsurgery.
Inmostcases,apixabandoesnotrequireroutinemonitoring.IttypicallyprolongsclottingtestssuchasPT/INRandaPTTso,ifnecessary,itisbestmeasuredusingananti-Xachromogenicassay.Note thatthiscontrol isforresearchuseonlyintheUSandCanada.
