Description:
Technoview®rivaroxabancalibratorset-high isasetofplasma-derivedcalibration sampleswithrivaroxaban*concentrations rangingfrom~0-500ng/ml. Thesetcanbeusedfor establishingastandardcurveinresearchmeasurementsofrivaroxaban. Itisoptimizedforusewithanti-Xachromogenicassaysand isfrequentlyusedinconjunctionwiththe Technoview®rivaroxaban low,mediumandhighcontrolsinthe Technochrom®anti-Xachromogenicassay.
*Rivaroxaban istheactivesubstanceinXarelto®.
Advantages:
- Allowsforestablishmentofcalibrationcurvecoveringarangeof0-500ng/ml
- Optimizedforusewithanti-Xa(withoutexogeneousantithrombin) research assaysbut canbevalidated foruseinprothrombintime(PT)researchassays
CalibratorSetComposition:
5x1mlvialswitharangeofrivaroxaban concentrations:
- Cal1:0ng/ml
- Cal2:50ng/ml
- Cal3:100ng/ml
- Cal4:200ng/ml
- Cal5:500ng/ml
Calibratorsare lyophilizedandpreparedfrompooledhumancitratedplasmasupplementedwithdifferent concentrationsofrivaroxaban.TheplasmacontainsstABIlizersbutnobactericideadditives. Theyarecalibrated,usingahighperformanceliquidchromatography-tandemmassspectrometryassay,againstarivaroxabanstructuralanalogue.
Background:
Rivaroxaban(Xarelto®)isanoraldirectfactorXainhibitordrug.Itisprescribedbyahealthcareproviderandcan:
- reducetheriskofbloodclotsandstrokeinindividuals whohavenonvalvularatrialfibrillation;
- treatdeepveinthrombosis(DVT)andpulmonaryembolism(PE);and
- reducetheriskofDVTandPEinindividuals afterhiporkneereplacementsurgery.
Inmostcases,rivaroxabandoesnotrequireroutinemonitoring.IttypicallyprolongsclottingtestssuchasPT/INRandaPTTsoitisbestmonitoredusinganti-Xachromogenicassays.NotethatthiscalibratorsetisforresearchuseonlyintheUSandCanada.
