Description:

ChromogenixLowMolecularWeight(LMW)HeparinCalibrationPlasma

isforpreparationofcalibrationcurvesforuseinchromogenicheparinassays.

Composition:

Reagents, Packaging,StorageandStABIlity

• CalibrationPlasmaLMWHeparin1:4x1mlvials(0.0IU/ml)ofalyophilizedpowderofhumanplasmacontainingdefinedIU/mLoflowmolecularweight(LMW)heparin.
• CalibrationPlasmaLMWHeparin2:4x1mlvials(0.4IU/ml)ofalyophilizedpowderofhumanplasmacontainingdefinedIU/mLoflowmolecularweight(LMW)heparin.
• CalibrationPlasmaLMWHeparin3:4x1mlvials(0.8IU/ml)ofalyophilizedpowderofhumanplasmacontainingdefinedIU/mLoflowmolecularweight(LMW)heparin.

Unopenedcalibratorsarestableuntiltheexpirationdateshownonthevialwhenstoredat2-8°C.Stabilityafterreconstitution:24hoursat20-25°C,or14daysat2-8°Cintheoriginalvial.

Calibration:

Lyophilizedhumanplasma,preparedbyadditionofLMWheparin.Calibratedagainstthe1stInternationalWHOstandard(LMWheparin).Forconstructionofcalibrationcurvesforuseinchromogenicheparinassays.

Background:

Heparinisthemostfrequentlyusedantithrombotictherapeuticdrug.TheBIOLOGicalactivityofthissulfatedglycosaminoglycanresidesinitsabilitytoaccelerate(upto2000-fold)theinhibitoryeffectofantithrombin(AT)onthecoagulationproteases.TheLevel1,2and3ofCalibrationPlasmaLMWHeparinarepreparedbymeansofadedicatedprocessandcontaindifferentconcentrationofLMWHeparin.Calibrators1,2and3areintendedfortheassessmentofcalibrationcurveoftheHeparinassay.